As he celebrates his birthday on May 6, take a look at images of George Clooney throughout his career.
"O Brother, Where Art Thou?," the Coen Brothers' 2000 take on Homer's "Odyssey," gave Clooney the chance to have the best-reviewed performance of his career to that point.
Karen Ducey/Getty Images
Theo Wargo/Getty Images
Frazer Harrison/Getty Images
Thomas Reiner/CNN iReport
Stephen Maturen/Getty Images
Scott Olson/Getty Images
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