Chris Parmelee hit a game-ending homer in the ninth inning and the Minnesota Twins overcame David Ortiz's big night to beat the Boston Red Sox 8-6 on Tuesday.
Ortiz went 4 for 5 with two homers and four RBIs, but it wasn't enough.
Kurt Suzuki singled with two outs off reliever Andrew Miller (1-1) before Parmelee lined an 0-1 pitch into the right-field seats for his first two RBIs of the season.
Eduardo Nunez homered and Brian Dozier had two RBIs in a five-run second for Minnesota.
Ortiz hit solo homers in the first and fourth and is tied with Jim Rice on the Red Sox list with 382. It was the 42nd multihomer game for Big Papi, who began his career with the Twins.
Ortiz added an RBI single in the sixth and another one in the seventh that made it 6-5.