MILWAUKEE (AP) -- Jean Segura hit a three-run homer, and the Milwaukee Brewers broke out of an offensive slumber at home to support Kyle Lohse in a 5-2 win over the San Diego Padres on Wednesday night.

Segura homered for a 4-1 lead in the second. Khris Davis added a solo shot for the Brewers, who have won five of six and are a big league-best 16-6.

Lohse (4-1) allowed five hits and no walks in seven innings. Brewers batters backed him with nine hits at Miller Park, where the team had been averaging just two runs and six hits entering the night.

Francisco Rodriguez pitched a scoreless ninth for his ninth save, his 313th over 12 full big league seasons.

Tyson Ross (2-3) allowed a season-high five earned runs in six innings.

Ross regressed after striking out nine and shutting out the Giants over eight innings in his previous start last week. He had little to celebrate Wednesday, a day after he turned 27.

Milwaukee was aggressive from the outset and made solid contact early in counts. Ryan Braun doubled home a run in the first on a 1-1 pitch, the same count on which eighth-place hitter Segura hit a 385-homer off the green facade over the left-field wall.

Waiting in the on-deck circle, Lohse pumped his right fist in the air as Segura's drive cleared the fence. On the mound, the right-hander held the Padres to one earned run until the bullpen shut down San Diego over the final two innings.

San Diego took a 1-0 lead in the first off of Seth Smith's sacrifice fly, but was otherwise limited until pinch-hitter Nick Hundley's RBI single with two outs in the seventh.

After four straight one-run games, the Brewers got a relative breather. Manager Ron Roenicke said it was only a matter of time before his squad broke out of its hitting slump at home - and his players backed him up with four runs and five hits in the first two innings.

Getting the 24-year-old Segura going will help. Segura, who was dropped from second to eighth in the order after starting the season hitting .232, hit his first homer since July 30, spanning 269 plate appearances.

NOTES: A fan sitting in the front row next to the Brewers dugout left with an ice pack on her right wrist after apparently being hit by a bat that flew out of the hands of Padres pinch-hitter Yasmani Grandal in the seventh on a strikeout. ... Padres manager Bud Black said RHP Josh Johnson is scheduled for elbow ligament-replacement surgery for the second time in his career and will miss the entire season. Johnson was placed on the DL before the season began. ... Brewers RHP Brandon Kintzler (rotator cuff) had a 40-pitch bullpen session on Wednesday and appears on track to return from the DL on Friday. The setup man has been sidelined since April 9. ... The Padres will send LHP Eric Stults (1-2) to the hill when they begin a three-game series in Washington on Thursday. ... The Brewers are off Thursday and plan to start RHP Matt Garza (0-2) at home against the Cubs on Friday.