MILWAUKEE (AP) -- Yuniesky Betancourt hit a grand slam, and Carlos Gomez and Norichika Aoki also homered as the Milwaukee Brewers used an eight-run third inning to beat Barry Zito and the San Francisco Giants 10-8 on Tuesday night.
Betancourt's fifth career grand slam highlighted the seven-hit inning that chased Zito, who hadn't lost since last August against the New York Mets. Rickie Weeks doubled home two runs and Jonathan Lucroy added a two-run single as the Brewers sent 12 batters to the plate. Zito faced 11 of them.
Zito (2-1) had opened the season with consecutive scoreless seven-inning games. He struck out five and walked two in 2 2-3 innings and his 0.00 ERA ballooned to 4.86 ERA. Dating to last season, the Giants had won the previous 13 regular-season games started by Zito.
Gomez's home run off the foul pole in left snapped Zito's scoreless streak to start the season at 15 2-3 innings. Zito is 0-5 in eight starts at Miller Park and has never lasted more than 5 2-3 innings.
Jim Henderson pitched the ninth for his second save, but gave up a run to Brandon Belt, who went 3 for 4.
Brandon Kintzler (2-0) got the win in relief for the Brewers.
Wily Peralta started for Milwaukee and gave up three runs, two earned, in the third inning, and then left in the fifth with bases loaded and nobody out. He went four innings, allowed six runs, five earned, on seven hits with three walks and a strikeout in his first career start against the Giants.
In the third, Angel Pagan had an RBI single and Pablo Sandoval's double knocked in Pagan and Marco Scutaro, who had reached on third baseman Alex Gonzalez's throwing error.
In the fifth, Peralta, who the Brewers are counting on to be a reliable third starter, gave up Sandoval's run-scoring single and then left the bases loaded and no outs for Mike Fiers. He got the first out, but then allowed Belt's sacrifice fly. Gregor Blanco lined out to right to end the threat.
Trying to protect a three-run lead, Fiers left the bases loaded with one out in the sixth. Kintzler came on and gave up a sacrifice fly to Sandoval, but then struck out Buster Posey to end the top of the sixth.
Brandon Crawford hit his second home run of the season, a solo shot, in the fourth.
NOTES: Brewers pitcher Yovani Gallardo was arrested on a drunken-driving charge Tuesday after authorities said he was driving on a city highway with a blood-alcohol content nearly three times the legal limit. He pitches Thursday in the final of the three-game series with the Giants. ... The Giants and Brewers held a moment of silence for the victims of the tragedy at the Boston Marathon. ... Giants and Brewers players, managers and coaches wore uniform No. 42 in honor of Jackie Robinson. ... Ryan Braun struck out four times. ... The Brewers improved to 2-5 at home. The other win came on opening say when they beat the Colorado Rockies 5-4 in 10 innings.