(CNN) -

Looking for the best hospitals in the United States? U.S. News & World Report has released its annual rankings for 2014 -- with the Mayo Clinic topping the site's honor roll list for the first time.

The yearly analysis specifically looks at the best medical centers for patients with life-threatening or rare conditions. Factors such as patient survival rates, adequate nursing staff, reputation with specialist physicians and patient safety, which has more emphasis this year, are taken into account.

"U.S. News strives to provide patients and their families with the most comprehensive data available on hospitals," said Avery Comarow, U.S. News health rankings editor. "With an estimated 400,000 deaths occurring in hospitals each year from medical errors, measuring safety performance is critical to understanding how well a hospital cares for its patients."

In addition to an overall ranking, the report also breaks down the best hospitals into 16 specialties, including the best hospitals for cancer and heart surgery.

All the rankings can be viewed on usnews.com. Highlights include:

Best overall hospitals

1. Mayo Clinic, Rochester, Minnesota

2. Massachusetts General Hospital, Boston

3. Johns Hopkins Hospital, Baltimore

4. Cleveland Clinic

5. UCLA Medical Center, Los Angeles

Best cancer hospitals

1. Memorial Sloan Kettering Cancer Center, New York

2. University of Texas MD Anderson Cancer Center, Houston

3. Mayo Clinic, Rochester, Minnesota

4. Dana-Farber/Brigham and Women's Cancer Center, Boston

5. Johns Hopkins Hospital, Baltimore

Best cardiology and heart surgery hospitals

1. Cleveland Clinic

2. Mayo Clinic, Rochester, Minnesota

3. New York-Presbyterian University Hospital of Columbia and Cornell, New York

4. Duke University Hospital, Durham, North Carolina

5. Brigham and Women's Hospital, Boston

For less life-threatening conditions, U.S. News and World Report recommends that patients use the best regional hospitals list.

America's top hospitals of 2014

Published On: Jul 16 2013 11:14:34 AM CDT   Updated On: Jul 15 2014 09:37:16 AM CDT

The Mayo Clinic has been named America's new best hospital. Find out what other U.S. health care facilities made this year's list of the country's top hospitals.

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U.S. World & News Report has come out with its annual list of the country's best hospitals. Minnesota's Mayo Clinic is No. 1 for the first time. Take a look at the top 10 best hospitals in the U.S.